Phenotypes Associated with This Genotype

Genotype
MGI:3802931

• Allelic Composition: Igkc^tm1Jkbv/Igkc^tm1Jkbv; Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:137738 )

• B cells exclusively express lambda light chain and not kappa light chain

decreased immature B cell number ( J:137738 )

• immature B cells in circulation are at 70% of wild-type levels

decreased mature B cell number ( J:137738 )

• mature B cells are at 50-60% of wild-type levels in the spleen

• mature B cells in the blood and lymph nodes are 20-25% higher than in Igk-C^tm1Jkbv homozygotes

• mature B cells expressing human kappa light chain are twice as common as B cells expressing murine lambda light chain

increased pre-B cell number ( J:137738 )

• there is a 2-fold accumulation of small pre- B cells in the bone marrow

abnormal immunoglobulin level ( J:137738 )

• the concentration of antibodies containing murine lambda light chain are reduced to levels of 300 micrograms per ml compared to 580 micrograms per ml in Igk-C^tm1Jkbv homozygotes

• the concentration of antibodies containing human kappa light chain is 720 micrograms per ml in sera

hematopoietic system

abnormal B cell differentiation ( J:137738 )

• B cells exclusively express lambda light chain and not kappa light chain

decreased immature B cell number ( J:137738 )

• immature B cells in circulation are at 70% of wild-type levels

decreased mature B cell number ( J:137738 )

• mature B cells are at 50-60% of wild-type levels in the spleen

• mature B cells in the blood and lymph nodes are 20-25% higher than in Igk-C^tm1Jkbv homozygotes

• mature B cells expressing human kappa light chain are twice as common as B cells expressing murine lambda light chain

increased pre-B cell number ( J:137738 )

• there is a 2-fold accumulation of small pre- B cells in the bone marrow

abnormal immunoglobulin level ( J:137738 )

• the concentration of antibodies containing murine lambda light chain are reduced to levels of 300 micrograms per ml compared to 580 micrograms per ml in Igk-C^tm1Jkbv homozygotes

• the concentration of antibodies containing human kappa light chain is 720 micrograms per ml in sera