Phenotypes Associated with This Genotype

Genotype
MGI:3802925

• Allelic Composition: Igh-J^tm1Jkbv/Igh-J^tm1Jkbv; Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:137738 )

• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells

decreased immature B cell number ( J:137738 )

• immature circulating B cells are at levels that are 80% of normal

increased late pro-B cell number ( J:137738 )

• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43⁺ CD45⁺ HSA^med BP-1⁺) step

decreased mature B cell number ( J:137738 )

• the levels of circulating mature B cells are 20% of the numbers found in wild-type

• these B cells express human mu heavy chain

• these mature B cells numbers are twice those found in Ihg-J null mice that are hemizygote for the transgene

decreased pre-B cell number ( J:137738 )

• large pre-B cells numbers in the bone marrow are 50% of wild-type

abnormal immunoglobulin level ( J:137738 )

• antibodies containing human mu heavy chains are found in the sera at levels of 60 micrograms per ml

hematopoietic system

abnormal B cell differentiation ( J:137738 )

• B cells develop inefficiently with a partial block occurring at the transition from pre- to pro- B cells

decreased immature B cell number ( J:137738 )

• immature circulating B cells are at levels that are 80% of normal

increased late pro-B cell number ( J:137738 )

• late pro B-cells accumulate at numbers 3- fold higher than in wild-type at the fraction C (CD43⁺ CD45⁺ HSA^med BP-1⁺) step

decreased mature B cell number ( J:137738 )

• the levels of circulating mature B cells are 20% of the numbers found in wild-type

• these B cells express human mu heavy chain

• these mature B cells numbers are twice those found in Ihg-J null mice that are hemizygote for the transgene

decreased pre-B cell number ( J:137738 )

• large pre-B cells numbers in the bone marrow are 50% of wild-type

abnormal immunoglobulin level ( J:137738 )

• antibodies containing human mu heavy chains are found in the sera at levels of 60 micrograms per ml