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Phenotypes Associated with This Genotype
Genotype
MGI:3802917
Allelic
Composition		 ApoeTg(rtTA)1Gaga/ApoeTg(rtTA)1Gaga
Igs7tm1(tetO-Apoe)Gaga/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApoeTg(rtTA)1Gaga mutation (0 available); any Apoe mutation (163 available)
Igs7tm1(tetO-Apoe)Gaga mutation (0 available); any Igs7 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased susceptibility to atherosclerosis ( J:136987 )
• mice exhibit an increased susceptibility to forming athelerosclerotic lesions compared to wild-type mice
• however, treatment with doxycycline reduces susceptibility to normal

homeostasis/metabolism
increased circulating cholesterol level ( J:136987 )
• plasma cholesterol levels are elevated compared to in wild-type mice
• however, treatment with doxycycline returns plasma cholesterol levels to normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory