Phenotypes Associated with This Genotype

Genotype
MGI:3802681

• Allelic Composition: Igh-J^tm1Jkbv/Igh-J^tm1Jkbv; Igkc^tm1Jkbv/Igkc^tm1Jkbv; Tg(IGH@yH1)2BJkbv/0; Tg(IGK@yK1)9.2CJkbv/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell morphology ( J:23827 )

• 43% of B cells express human mu heavy chain and human kappa light chain

• 57% of B cells express human mu heavy chain and mouse lamda light chain

• no co-expression of human and mouse light chain is found

increased mature B cell number ( J:23827 )

• the presence of the two transgenes overcomes the block in B cell development that occurs in Igh-J^tm1Jkbv Igk-C^tm1Jkbv double homozygotes

• mature B cells are found at a level 10% of that in wild-type mice

abnormal immunoglobulin level ( J:23827 )

• human antibodies occur in the sera of mice at 10 micrograms per ml

• this concentration is several hundred fold higher than occurs in transgenic mice that do not have endogenous Ig heavy and light chains inactivated

hematopoietic system

abnormal B cell morphology ( J:23827 )

• 43% of B cells express human mu heavy chain and human kappa light chain

• 57% of B cells express human mu heavy chain and mouse lamda light chain

• no co-expression of human and mouse light chain is found

increased mature B cell number ( J:23827 )

• the presence of the two transgenes overcomes the block in B cell development that occurs in Igh-J^tm1Jkbv Igk-C^tm1Jkbv double homozygotes

• mature B cells are found at a level 10% of that in wild-type mice

abnormal immunoglobulin level ( J:23827 )

• human antibodies occur in the sera of mice at 10 micrograms per ml

• this concentration is several hundred fold higher than occurs in transgenic mice that do not have endogenous Ig heavy and light chains inactivated