Phenotypes Associated with This Genotype

Genotype
MGI:3802680

• Allelic Composition: Tg(IGH@yH1)2BJkbv/0; Tg(IGK@yK1)9.2CJkbv/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell morphology ( J:23827 )

• 0.8-3.9% of B cells express human mu heavy chain and 1.4-4.8% express human kappa chain

• 0.06% to 0.27% of B cells express both the human heavy and light chains

abnormal immunoglobulin level ( J:23827 )

• human antibodies are found in the serum at 0.3 to 0.7 micrograms per ml

• antigen specific human antibodies are generated when mice are immunized with tetanus toxin fragment

hematopoietic system

abnormal B cell morphology ( J:23827 )

• 0.8-3.9% of B cells express human mu heavy chain and 1.4-4.8% express human kappa chain

• 0.06% to 0.27% of B cells express both the human heavy and light chains

abnormal immunoglobulin level ( J:23827 )

• human antibodies are found in the serum at 0.3 to 0.7 micrograms per ml

• antigen specific human antibodies are generated when mice are immunized with tetanus toxin fragment