Phenotypes Associated with This Genotype

Genotype
MGI:3802679

• Allelic Composition: Igh-J^tm1Jkbv/Igh-J^tm1Jkbv; Tg(IGH@yH1)2BJkbv/0; Tg(IGK@yK1)9.2CJkbv/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell morphology ( J:23827 )

• all B cells express human mu heavy chain immunoglobulin with most of the B cells also expressing human delta heavy chain

increased late pro-B cell number ( J:23827 )

• late pro-B cell numbers are increased more than 2-fold compared to wild-type mice suggesting a less efficient V to DJ joining process

increased mature B cell number ( J:23827 )

• the presence of the two transgenes rescues the block in B cell development that occurs in Igh-J^tm1Jkbv development

• mature B cells are found in the bone marrow, spleen and blood in numbers corresponding to 58%, 55%, and 30% of wild-type levels

abnormal immunoglobulin level ( J:23827 )

• antibodies containing human mu heavy chain are found in the serum at a concentration of 350 micrograms per ml, a level over 500 fold higher than found in transgenic mice without the Igh-J targeted mutation

• the serum concentration of antibodies with human mu heavy chain is only 2- to 3- fold lower than the concentration of IgM found in humans

immune system

abnormal B cell morphology ( J:23827 )

• all B cells express human mu heavy chain immunoglobulin with most of the B cells also expressing human delta heavy chain

increased late pro-B cell number ( J:23827 )

• late pro-B cell numbers are increased more than 2-fold compared to wild-type mice suggesting a less efficient V to DJ joining process

increased mature B cell number ( J:23827 )

• the presence of the two transgenes rescues the block in B cell development that occurs in Igh-J^tm1Jkbv development

• mature B cells are found in the bone marrow, spleen and blood in numbers corresponding to 58%, 55%, and 30% of wild-type levels

abnormal immunoglobulin level ( J:23827 )

• antibodies containing human mu heavy chain are found in the serum at a concentration of 350 micrograms per ml, a level over 500 fold higher than found in transgenic mice without the Igh-J targeted mutation

• the serum concentration of antibodies with human mu heavy chain is only 2- to 3- fold lower than the concentration of IgM found in humans