Phenotypes Associated with This Genotype

Genotype
MGI:3802678

• Allelic Composition: Tg(IGK@yK1)9.2CJkbv/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell morphology ( J:23827 )

• 9.3% of B cells express human kappa light chain

• 80% of the B cells that express human kappa light chain do not express endogenous murine light chains

abnormal immunoglobulin light chain V-J recombination ( J:23827 )

• the V and J segments of the human transgene undergo recombination within B cells

abnormal immunoglobulin level ( J:23827 )

• antibodies containing the human kappa light chain is found in the sera at 17.7 micrograms per ml

hematopoietic system

abnormal B cell morphology ( J:23827 )

• 9.3% of B cells express human kappa light chain

• 80% of the B cells that express human kappa light chain do not express endogenous murine light chains

abnormal immunoglobulin light chain V-J recombination ( J:23827 )

• the V and J segments of the human transgene undergo recombination within B cells

abnormal immunoglobulin level ( J:23827 )

• antibodies containing the human kappa light chain is found in the sera at 17.7 micrograms per ml