Phenotypes Associated with This Genotype

Genotype
MGI:3802667

• Allelic Composition: Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue morphology ( J:137598 )

• triglyceride content of brown adipose tissue is increased compared to in wild-type mice

• mitochondria density is decreased compared to in wild-type mice

• brown adipose tissue mitochondria exhibit reduced cristae density compared to in wild-type mice

abnormal fat cell morphology ( J:137598 )

• brown adipocytes exhibit increased lipid droplet size and density compared to in wild-type mice

homeostasis/metabolism

decreased triglyceride level ( J:137598 )

• triglyceride content of brown adipose tissue is increased compared to in wild-type mice

cardiovascular system

abnormal blood circulation ( J:137598 )

• heart performance is reduced compared to in wild-type mice but not as severely as in Ppargc1a^tm1Dpk Ppargc1b^tm1.1Dpk homozygotes