Phenotypes for Ppargc1a Ppargc1b MGI:3802665 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk Ppargc1b^tm1.1Dpk/Ppargc1b⁺
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1a^tm1Dpk mutation (1 available); any Ppargc1a mutation (47 available)
Ppargc1b^tm1.1Dpk mutation (1 available); any Ppargc1b mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired adaptive thermogenesis ( J:137598 )

• mice exhibit reduced capacity to regulate core temperature after 2 hours of cold exposure compared to wild-type and Ppargc1b^tm1.1Dpk homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23