mortality/aging
• 67% of mice die within 24 hours of birth
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• all mice die by day 7
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cardiovascular system
• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice
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• similar to that found in Ppargc1atm1Dpk Ppargc1btm1.1Dpk homozygotes
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muscle
• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice
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