Phenotypes for Ppargc1a Ppargc1b Tg(Myh6-cre)2182Mds MGI:3802663 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Ppargc1a^tm1Dpk/Ppargc1a^tm1Dpk Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1a^tm1Dpk mutation (1 available); any Ppargc1a mutation (47 available)
Ppargc1b^tm1Dpk mutation (1 available); any Ppargc1b mutation (59 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:137598 )

• all mice die by day 7

neonatal lethality, incomplete penetrance ( J:137598 )

• 67% of mice die within 24 hours of birth

cardiovascular system

abnormal myocardium layer morphology ( J:137598 )

• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice

decreased cardiac output ( J:137598 )

• similar to that found in Ppargc1a^tm1Dpk Ppargc1b^tm1.1Dpk homozygotes

muscle

abnormal myocardium layer morphology ( J:137598 )

• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/20/2026 MGI 6.24