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Phenotypes Associated with This Genotype
Genotype
MGI:3802663
Allelic
Composition
Ppargc1atm1Dpk/Ppargc1atm1Dpk
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1atm1Dpk mutation (1 available); any Ppargc1a mutation (47 available)
Ppargc1btm1Dpk mutation (1 available); any Ppargc1b mutation (56 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 67% of mice die within 24 hours of birth

cardiovascular system
• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice
• similar to that found in Ppargc1atm1Dpk Ppargc1btm1.1Dpk homozygotes

muscle
• after birth, myocytes exhibit a reduction in mitochondrial number and size compared to in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory