Phenotypes Associated with This Genotype

Genotype
MGI:3802638

• Allelic Composition: Mlst8^tm1Lex/Mlst8^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137592 )

• mice die at around E10.5

embryo

abnormal vitelline vasculature morphology ( J:137592 )

embryonic growth retardation ( J:137592 )

decreased embryo size ( J:137592 )

abnormal placenta morphology ( J:137592 )

• the interface between the trophoblast giant cell layer and the labyrinth is somewhat disorganized

thick placenta labyrinth ( J:137592 )

• thicker than in wild-type mice

nervous system

abnormal brain development ( J:137592 )

• despite no change in apoptosis or cell cycling rates, cephalic regions fail to develop

abnormal telencephalon development ( J:137592 )

• telencephalic vesicles are underdeveloped

cardiovascular system

abnormal vitelline vasculature morphology ( J:137592 )

dilated vasculature ( J:137592 )

• in the head at E10.5

abnormal heart development ( J:137592 )

• the cardiac wall is slightly thinner than in wild-type mice

internal hemorrhage ( J:137592 )

• at E9.5, mice occasionally exhibit internal hemorrhage

growth/size/body

embryonic growth retardation ( J:137592 )

decreased embryo size ( J:137592 )