Phenotypes Associated with This Genotype

Genotype
MGI:3801613

• Allelic Composition: Il21r^tm1Kopf/Il21r^tm1Kopf
• Genetic Background: involves: 129/Sv * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:137377 )

N • normal frequency of IFN gamma and IL17 producing CD4+ T cells when mice are immunized with an alpha myosin peptide

impaired eosinophil recruitment ( J:137508 )

• after intranasal OVA challenge of OVA immunized mice

abnormal lymphocyte physiology ( J:137508 )

• after intranasal OVA challenge of OVA immunized mice reduced proliferation of lymphocytes is seen

abnormal immunoglobulin level ( J:137508 )

decreased IgA level ( J:137508 )

• of OVA specific IgA in broncho-alveolar lavage fluid and in serum

increased IgE level ( J:137508 )

• elevated 2 fold

decreased IgG1 level ( J:137508 )

• of OVA specific IgG1 in broncho-alveolar lavage fluid and in serum

hematopoietic system

impaired eosinophil recruitment ( J:137508 )

• after intranasal OVA challenge of OVA immunized mice

abnormal lymphocyte physiology ( J:137508 )

• after intranasal OVA challenge of OVA immunized mice reduced proliferation of lymphocytes is seen

abnormal immunoglobulin level ( J:137508 )

decreased IgA level ( J:137508 )

• of OVA specific IgA in broncho-alveolar lavage fluid and in serum

increased IgE level ( J:137508 )

• elevated 2 fold

decreased IgG1 level ( J:137508 )

• of OVA specific IgG1 in broncho-alveolar lavage fluid and in serum