Phenotypes Associated with This Genotype

Genotype
MGI:3801468

• Allelic Composition: Bcl2l1^tm1Ywh/Bcl2l1^tm1Ywh; Mcl1^tm1Ywh/Mcl1^tm1Ywh; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased double-positive T cell number ( J:137400 )

• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice

• the absolute number of double positive cells is 10% of wild-type

absent CD4-positive, alpha-beta T cells ( J:137400 )

absent CD8-positive, alpha-beta T cells ( J:137400 )

hematopoietic system

decreased double-positive T cell number ( J:137400 )

• the frequency of double positive T cells is reduced to 45% of thymocytes compared to 85% in wild-type mice

• the absolute number of double positive cells is 10% of wild-type

absent CD4-positive, alpha-beta T cells ( J:137400 )

absent CD8-positive, alpha-beta T cells ( J:137400 )