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Phenotypes Associated with This Genotype
Genotype
MGI:3801466
Allelic
Composition
Mcl1tm1Ywh/Mcl1tm1Ywh
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Ywh mutation (0 available); any Mcl1 mutation (36 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the number of mature T cells in the spleen is less than 10% of wild-type
• slight increase in the frequency
• the number of mature T cells in the spleen is less than 10% of wild-type
• the frequency of total CD4+ thymocytes and mature CD4+ thymocytes is decreased compared to in wild-type mice
• few CD4+ T cells are detected
• the frequency of CD8+ T cells is reduced by greater than 80% compared to in wild-type mice
• the frequency of mature CD8+ thymocytes is reduced over 10-fold compared to in wild-type mice
• few CD8+ T cells are detected

hematopoietic system
• the number of mature T cells in the spleen is less than 10% of wild-type
• slight increase in the frequency
• the number of mature T cells in the spleen is less than 10% of wild-type
• the frequency of total CD4+ thymocytes and mature CD4+ thymocytes is decreased compared to in wild-type mice
• few CD4+ T cells are detected
• the frequency of CD8+ T cells is reduced by greater than 80% compared to in wild-type mice
• the frequency of mature CD8+ thymocytes is reduced over 10-fold compared to in wild-type mice
• few CD8+ T cells are detected

cellular
• the number of mature T cells in the spleen is less than 10% of wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory