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Phenotypes Associated with This Genotype
Genotype
MGI:3801464
Allelic
Composition
Mcl1tm1Ywh/Mcl1tm1Ywh
Tg(Lck-cre)548Jxm/0
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Ywh mutation (0 available); any Mcl1 mutation (36 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
• thymus contain 5% of the cells found in wild-type mice
• T cell development is blocked between DN2/3 and DN4 stages
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
• 5% to 10% of wild-type
• T cell numbers in the spleen are 40% to 50% of wild-type

hematopoietic system
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
• thymus contain 5% of the cells found in wild-type mice
• T cell development is blocked between DN2/3 and DN4 stages
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice
• T cell numbers in the spleen are 40% to 50% of wild-type
• 5% to 10% of wild-type

cellular
• apoptosis of DN thymocytes is increased 2-fold compared to in wild-type mice

endocrine/exocrine glands
• thymus contain 5% of the cells found in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory