mortality/aging
• fewer than expected mice survive until weaning (2% compared to the expected 25%) with mice dying 10 to 21 days after birth
|
growth/size/body
• at E10.5
|
• postnatally and after weaning
|
nervous system
• in 20% of mice at E18.5
|
exencephaly
(
J:132940
)
• in 15% mice at E18.5
|
respiratory system
• mice removed from mothers at E18.5 die within minutes with difficulty breathing
|
embryo
• at E10.5
|
• in 20% of mice at E18.5
|