Phenotypes for Gsk3b Tph2 MGI:3801154 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Gsk3b^tm1Jrw/Gsk3b⁺ Tph2^tm1Mca/Tph2^tm1Mca
Genetic Background	involves: 129 * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3b^tm1Jrw mutation (0 available); any Gsk3b mutation (111 available)
Tph2^tm1Mca mutation (3 available); any Tph2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:131619 )

N	• the Gsk3b allele rescues the aberrant behaviors observed in Tph2 homozygotes; mice exhibit normal immobility times in the tail suspension test, normal behavior in dark-light emergence test and normal aggression towards males

abnormal social investigation ( J:131619 )

• mutants display enhanced social investigation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23