Phenotypes Associated with This Genotype

Genotype
MGI:3801045

• Allelic Composition: Otx2^tm3Tlam/Otx2^tm3Tlam
• Genetic Background: 129/Sv-Otx2^tm3Tlam

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:130649 )

• homozygotes are found in mendelian proportions up to birth, however only 4% of the expected 25% are seen around weaning, indicating postnatal lethality

craniofacial

abnormal facial morphology ( J:130649 )

• variable facial abnormalities

nervous system

abnormal brain development ( J:130649 )

• variable brain reduction from E9.5 on

abnormal midbrain morphology ( J:130649 )

• marker analysis shows complete disappearance of the mesencephalon

abnormal diencephalon morphology ( J:130649 )

• marker analysis shows partial disappearnce of the diencephalon

growth/size/body

abnormal facial morphology ( J:130649 )

• variable facial abnormalities