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Phenotypes Associated with This Genotype
Genotype
MGI:3801012
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(Prnp-Abca1)EHol/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Tg(Prnp-Abca1)EHol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:131400 )
• frequent deposits are observed in hilus of dentate gyrus
• almost no thioflavin-S positive fibrillar Abeta plaques are observed in cortex and hippocampus
• mice show 2- to 3-fold less Abeta in the brain relative to Tg(APPV717F)109Ili, Apoe-wild-type controls

homeostasis/metabolism
amyloid beta deposits ( J:131400 )
• frequent deposits are observed in hilus of dentate gyrus
• almost no thioflavin-S positive fibrillar Abeta plaques are observed in cortex and hippocampus
• mice show 2- to 3-fold less Abeta in the brain relative to Tg(APPV717F)109Ili, Apoe-wild-type controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory