Phenotypes for Tg(Prnp-Abca1)EHol MGI:3801010 MGI Mouse

multinucleated giant male germ cells ( J:131400 )

• 3-fold increased numbers of apoptotic cells in testes relative to controls

seminiferous tubule degeneration ( J:131400 )

• tubules display atrophy with marked degenerative changes such as large increase in multinucleated giant cells and cells with condensed nuclei

abnormal testis development ( J:131400 )

• testes exhibit maturation arrest due to absence of mature products of spermatogenesis

decreased testis weight ( J:131400 )

• 50% reduction in testes mass relative to wild-type controls

testicular atrophy ( J:131400 )

• severe atrophy

abnormal spermatogenesis ( J:131400 )

• elongated spermatids and spermatozoa are absent in testes of mutant males

male infertility ( J:131400 )

amyloid beta deposits ( J:131400 )

• in 12-month old mice have frequent amyloid beta (Abeta) deposits in cortex and hippocampus including molecular layer of hippocampus

• almost no deposits are observed in hilus of dentate gyrus of hippocampus

• thioflavin-S positive fibrillar Abeta plaques are frequently observed in cortex and hippocampus at 12 months

• thioflavin-S positive plaques are associated with reactive microglia

abnormal glial cell physiology ( J:131400 )

• Apoe-containing lipoprotein particles secreted by astrocytes contain more lipid than those secreted by non-transgenic controls; lipoprotein fractions contain a greater ratio of cholesterol to Apoe

homeostasis/metabolism phenotype ( J:131400 )

N	• plasma levels of cholesterol including HDL-associated cholesterol and phospolipids, and Apoe are not significantly different from controls at 3 months