Analysis Tools
immune system
| N |
• despite a lack of osteoclasts and macrocytic hyperchromic anemia, mice exhibit normal osteoclast progenitors, lymphocytes, platelets, granulocytes and monocyte numbers
• despite splenomegaly, spleen architecture is normal
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• despite normal cellularity, spleen weight is increased compared to in wild-type mice
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• when bone marrow is used to reconstitute a Rag1 null mouse, the number of B220+CD43-, B220+CD25+ and B220+sIgM+ B cell precursors in the bone marrow is decreased
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• when bone marrow is used to reconstitute a Rag1 null mouse
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• differentiation of CD4/CD8 double-negative CD44-CD25+ precursors to CD44-CD25- is blocked
• T cell development arrest is intrinsic as determined by bone marrow transplants
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• the number of IgM+sIgD+ or B220+sIgM+ B cells is decreased compared to in wild-type mice
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• absent
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• T cells are activated with wild-type dendritic cells or anti-CD23 and anti-CD28 antibodies, T cell IFN-gamma production is decreased compared to that of wild-type T cells
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• T cells are activated with wild-type dendritic cells or anti-CD23 and anti-CD28 antibodies, T cell IL-2 production is decreased compared to that of wild-type T cells
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• T cells are activated with anti-CD23 and anti-CD28 antibodies, T cell IL-4 production is decreased compared to that of wild-type T cells
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• T cells are activated with anti-CD23 and anti-CD28 antibodies, T cell IL-5 production is decreased compared to that of wild-type T cells
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• T cells are activated with anti-CD23 and anti-CD28 antibodies, T cell IL-6 production is decreased compared to that of wild-type T cells
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skeleton
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• mice exhibit a thin calvaria and reduced marrow spaces compared to in wild-type mice
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• absent
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• epiphysial growth plates lack the normal columnar structure of chondrocytes
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• at the ends
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• at 4 weeks of age, trabecular bone density in the metaphysis and total bone density in the diaphysis is increased compared to in wild-type mice
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• evident at 2 days of age as radio-opaque long bones, vertebral bodies and ribs
(J:52369)
|
endocrine/exocrine glands
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• differentiation and expansion of alveolar buds into mature lobulo-alveolar mammary structures is completely arrested at day 14.5 of pregnancy
• however, luminal expansion of epithelial ducts is normal
• mammary development during pregnancy cannot be rescued by wild-type stroma
• alveolar epithelial cell proliferation and survival is decreased compared to in wild-type mice
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• female mice fail to lactate and pups die within 48hrs of birth regardless of genotype
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craniofacial
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• mice exhibit a thin calvaria and reduced marrow spaces compared to in wild-type mice
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round face
(
J:52369
)
|
• mice older than 6 months develop round faces
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growth/size/body
round face
(
J:52369
)
|
• mice older than 6 months develop round faces
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• after weaning secondary to a failure of tooth eruption
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• despite normal cellularity, spleen weight is increased compared to in wild-type mice
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homeostasis/metabolism
| N |
• despite osteopetrosis, mice exhibit normal serum levels of calcium, phosphorus and alkaline phosphatase at 4 weeks of age
|
hematopoietic system
| N |
• despite a lack of osteoclasts and macrocytic hyperchromic anemia, mice exhibit normal osteoclast progenitors, lymphocytes, platelets, granulocytes and monocyte numbers
• despite splenomegaly, spleen architecture is normal
|
|
• despite normal cellularity, spleen weight is increased compared to in wild-type mice
|
|
• when bone marrow is used to reconstitute a Rag1 null mouse, the number of B220+CD43-, B220+CD25+ and B220+sIgM+ B cell precursors in the bone marrow is decreased
|
|
• when bone marrow is used to reconstitute a Rag1 null mouse
|
|
• differentiation of CD4/CD8 double-negative CD44-CD25+ precursors to CD44-CD25- is blocked
• T cell development arrest is intrinsic as determined by bone marrow transplants
|
|
• in the liver and spleen
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• mice exhibit mild macrocytic hyperchromic anemia
|
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• the number of IgM+sIgD+ or B220+sIgM+ B cells is decreased compared to in wild-type mice
|
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• absent
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reproductive system
|
|
• differentiation and expansion of alveolar buds into mature lobulo-alveolar mammary structures is completely arrested at day 14.5 of pregnancy
• however, luminal expansion of epithelial ducts is normal
• mammary development during pregnancy cannot be rescued by wild-type stroma
• alveolar epithelial cell proliferation and survival is decreased compared to in wild-type mice
|
integument
|
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• differentiation and expansion of alveolar buds into mature lobulo-alveolar mammary structures is completely arrested at day 14.5 of pregnancy
• however, luminal expansion of epithelial ducts is normal
• mammary development during pregnancy cannot be rescued by wild-type stroma
• alveolar epithelial cell proliferation and survival is decreased compared to in wild-type mice
|
|
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• female mice fail to lactate and pups die within 48hrs of birth regardless of genotype
|
