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Phenotypes Associated with This Genotype
Genotype
MGI:3800993
Allelic
Composition		 Fbn1Tsk/Fbn1+
Tgfb1tm1N/Tgfb1tm1N
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1Tsk mutation (2 available); any Fbn1 mutation (174 available)
Tgfb1tm1N mutation (0 available); any Tgfb1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality ( J:68448 )
• absence of tight skin heterozygous Tgfb1 null pups from several crosses of heterozygotes is indicative of embryonic loss

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory