Phenotypes Associated with This Genotype

Genotype
MGI:3800807

• Allelic Composition: Tg(MtTPRMET)243Lng/0
• Genetic Background: FVB/N-Tg(MtTPRMET)243Lng

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:71573 )

• one female mouse developed mammary cancer at 6 months of age

• multiparous female mice exhibit hypoplastic alveolar nodules that contain foci of microscopic carcinomas

• all multiparous female mice develop scirrhous, papillary, or nodular mammary tumors

increased lymphoma incidence ( J:71573 )

• at 6 to 9 months of age, female mice develop lymphoblastic lymphomas of the mammary gland and lymph nodes

increased sarcoma incidence ( J:71573 )

• female mice develop spindle cell sarcomas

increased osteosarcoma incidence ( J:71573 )

• at 18 months of age, one female mouse exhibited an orbital giant cell ostersarcoma

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:71573 )

♀ • multiparous females exhibit hypoplastic alveolar nodules

increased mammary gland tumor incidence ( J:71573 )

• one female mouse developed mammary cancer at 6 months of age

• multiparous female mice exhibit hypoplastic alveolar nodules that contain foci of microscopic carcinomas

• all multiparous female mice develop scirrhous, papillary, or nodular mammary tumors

integument

mammary gland alveolar hyperplasia ( J:71573 )

♀ • multiparous females exhibit hypoplastic alveolar nodules

increased mammary gland tumor incidence ( J:71573 )

• one female mouse developed mammary cancer at 6 months of age

• multiparous female mice exhibit hypoplastic alveolar nodules that contain foci of microscopic carcinomas

• all multiparous female mice develop scirrhous, papillary, or nodular mammary tumors

skeleton

increased osteosarcoma incidence ( J:71573 )

• at 18 months of age, one female mouse exhibited an orbital giant cell ostersarcoma