Phenotypes Associated with This Genotype

Genotype
MGI:3800787

• Allelic Composition: Akr1c18^tm1Mni/Akr1c18^tm1Mni
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

long gestation period ( J:129608 )

♀ • pregnancy is prolonged by 2 days in 2 of 11 mutants and by 1 day in 3 mutants and pseudopregnancy is extended by 2.5 days

prolonged diestrus ( J:129608 )

♀ • duration of continuous diestrus is prolonged by about 1.5 days

prolonged estrous cycle ( J:129608 )

♀

decreased litter size ( J:129608 )

• the number of pups, especially live pups, is decreased

homeostasis/metabolism

increased circulating progesterone level ( J:129608 )

• serum progesterone levels do decline before parturition as in wild-type and are low enough for delivery of pups, however levels are still 1.3 times higher than in wild-type