About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3800676
Allelic
Composition
Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ra+
Genetic
Background
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1Tsk mutation (2 available); any Fbn1 mutation (77 available)
Il4ratm1Sz mutation (1 available); any Il4ra mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• enlarged alveoli and a histologic picture of emphysema are found, similar to that seen in tight skin heterozygotes that are wildtype for Il4ra

immune system
• increased anti-topoisomerase antibodies relative to wildtype, but lower than in tight skin mice wildtype for Il4ra

integument
• the skin is as thick as tight skin heterozygotes wildtype for Il4ra

Mouse Models of Human Disease
OMIM ID Ref(s)
Emphysema, Hereditary Pulmonary 130700 J:68448


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory