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Phenotypes Associated with This Genotype
Genotype
MGI:3800676
Allelic
Composition
Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ra+
Genetic
Background
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1Tsk mutation (2 available); any Fbn1 mutation (86 available)
Il4ratm1Sz mutation (1 available); any Il4ra mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• enlarged alveoli and a histologic picture of emphysema are found, similar to that seen in tight skin heterozygotes that are wildtype for Il4ra

immune system
• increased anti-topoisomerase antibodies relative to wildtype, but lower than in tight skin mice wildtype for Il4ra

integument
• the skin is as thick as tight skin heterozygotes wildtype for Il4ra

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pulmonary emphysema DOID:9675 OMIM:130700
J:68448


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory