Mouse Genome Informatics
cx
    Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ra+

involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
respiratory system
• enlarged alveoli and a histologic picture of emphysema are found, similar to that seen in tight skin heterozygotes that are wildtype for Il4ra

immune system
• increased anti-topoisomerase antibodies relative to wildtype, but lower than in tight skin mice wildtype for Il4ra

integument
• the skin is as thick as tight skin heterozygotes wildtype for Il4ra

Mouse Models of Human Disease
OMIM IDRef(s)
Emphysema, Hereditary Pulmonary 130700 J:68448