Phenotypes for Fbn1 Il4ra MGI:3800676 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Fbn1^Tsk/Fbn1⁺ Il4ra^tm1Sz/Il4ra⁺
Genetic Background	involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1^Tsk mutation (2 available); any Fbn1 mutation (171 available)
Il4ra^tm1Sz mutation (2 available); any Il4ra mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

overexpanded pulmonary alveolus ( J:68448 )

• enlarged alveoli and a histologic picture of emphysema are found, similar to that seen in tight skin heterozygotes that are wildtype for Il4ra

immune system

increased autoantibody level ( J:68448 )

• increased anti-topoisomerase antibodies relative to wildtype, but lower than in tight skin mice wildtype for Il4ra

integument

thick skin ( J:68448 )

• the skin is as thick as tight skin heterozygotes wildtype for Il4ra

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary emphysema		DOID:9675	OMIM:130700	J:68448

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23