Analysis Tools
hematopoietic system
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• there is a 2-fold reduction in the number of HEL-specific B cells found in the spleen
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• HEL-specific B cells in the spleen have mostly have an immature phenotype
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• few HEL-specific B cells in the spleen are found in the follicular region or have surface markers indicative of follicular B cells
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• very few HEL-specific B cells in the spleen are found in the marginal zone or have surface markers indicative of the marginal zone phenotype
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immune system
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• there is a 2-fold reduction in the number of HEL-specific B cells found in the spleen
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• HEL-specific B cells in the spleen have mostly have an immature phenotype
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• few HEL-specific B cells in the spleen are found in the follicular region or have surface markers indicative of follicular B cells
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• very few HEL-specific B cells in the spleen are found in the marginal zone or have surface markers indicative of the marginal zone phenotype
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• B cells are anergic when stimulated with HEL antigen as determined by reduced antibody production, no upregulation of activation markers CD69 and CD86, and failure to increase size
• these anergic B cells have a short half-life of less than three days
• however, these anergic B cells can proliferate in response to BCR-independent activation
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