mortality/aging
• following treatment with L-NAME and a high salt diet, all mice die
• mice on a high salt diet exhibit increased lethality associated with brain hemorrhages
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cardiovascular system
• 2 mice treated with both L-NAME and a high salt diet exhibited a dissecting aortic aneurysm in addition to hemorrhagic stroke unlike similarly treated wild-type mice
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• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice
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• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice
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• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• following treatment with L-NAME and a high salt diet
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• following treatment with a high salt diet, mice exhibit an increase in systolic blood pressure not observed in similarly treated wild-type mice
• mice exhibit a higher systolic blood pressure than wild-type mice
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nervous system
• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice
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• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• following treatment with L-NAME and a high salt diet
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homeostasis/metabolism
• following treatment with L-NAME and a high salt diet
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growth/size/body
• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice
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