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Phenotypes Associated with This Genotype
Genotype
MGI:3800182
Allelic
Composition
Tg(hAGT)2041Sig/0
Tg(hREN)9Sig/0
Genetic
Background
involves: C3H/HeRos * C57BL/6J * C57BL/10Ros * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(hAGT)2041Sig mutation (1 available)
Tg(hREN)9Sig mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following treatment with L-NAME and a high salt diet, all mice die
• mice on a high salt diet exhibit increased lethality associated with brain hemorrhages

cardiovascular system
• 2 mice treated with both L-NAME and a high salt diet exhibited a dissecting aortic aneurysm in addition to hemorrhagic stroke unlike similarly treated wild-type mice
• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice
• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice
• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
• following treatment with L-NAME and a high salt diet
• following treatment with a high salt diet, mice exhibit an increase in systolic blood pressure not observed in similarly treated wild-type mice
• mice exhibit a higher systolic blood pressure than wild-type mice

nervous system
• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice
• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
• following treatment with L-NAME and a high salt diet

homeostasis/metabolism
• following treatment with L-NAME and a high salt diet

growth/size/body
• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory