Phenotypes Associated with This Genotype

Genotype
MGI:3799688

• Allelic Composition: Tg(KLK4mHEL)6Ccg/0; Tg(TcrHEL3A9)1Mmd/0
• Genetic Background: involves: C57BL/6 * C57BL/10 * C57BR/cd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased double-positive T cell number ( J:78309 )

decreased CD4-positive, alpha-beta T cell number ( J:78309 )

• there is a reduced number of CD4-positive thymocytes bearing the transgenic TCR

• the number of lymph node CD4 T cells bearing a transgenic TCR is reduced 10-fold compared to mice transgenic just for the TCR

hematopoietic system

decreased double-positive T cell number ( J:78309 )

decreased CD4-positive, alpha-beta T cell number ( J:78309 )

• there is a reduced number of CD4-positive thymocytes bearing the transgenic TCR

• the number of lymph node CD4 T cells bearing a transgenic TCR is reduced 10-fold compared to mice transgenic just for the TCR