immune system
• there is a skewing towards the CD-4 T cell subset in mice on a homozygote H2k/k background
• the ratio of T cell subsets in the thymus is skewed toward CD8 T cells on a heterozygote H2b/k background
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• 55.9% of the double-positive thymocytes express the transgenic TCR
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• 15% of total lymphocytes found in lymph nodes are CD4 T cells bearing the transgenic TCR
• CD4 T cells that express the transgenic TCR-beta chain also express low or high amounts of the TCR-alpha chain
• the CD4 T cells expressing the low amounts of transgenic TCR-alpha may also express endogenous TCR-alpha chains
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• CD 4 T cell numbers in the lymph nodes are reduced by about a third
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• in vitro TCR stimulation leads to reduced expression of CD69 compared to T cells from mice transgenic for just the TCR
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• CD4 T cells expressing the transgenic TCR proliferate in response to hen egg lysozyme
• proliferation occurs whether CD4 T cells are low or high expressers of the transgenic TCR-alpha chain
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hematopoietic system
• there is a skewing towards the CD-4 T cell subset in mice on a homozygote H2k/k background
• the ratio of T cell subsets in the thymus is skewed toward CD8 T cells on a heterozygote H2b/k background
|
• 55.9% of the double-positive thymocytes express the transgenic TCR
|
• 15% of total lymphocytes found in lymph nodes are CD4 T cells bearing the transgenic TCR
• CD4 T cells that express the transgenic TCR-beta chain also express low or high amounts of the TCR-alpha chain
• the CD4 T cells expressing the low amounts of transgenic TCR-alpha may also express endogenous TCR-alpha chains
|
• CD 4 T cell numbers in the lymph nodes are reduced by about a third
|
• in vitro TCR stimulation leads to reduced expression of CD69 compared to T cells from mice transgenic for just the TCR
|
• CD4 T cells expressing the transgenic TCR proliferate in response to hen egg lysozyme
• proliferation occurs whether CD4 T cells are low or high expressers of the transgenic TCR-alpha chain
|
endocrine/exocrine glands
• there is a skewing towards the CD-4 T cell subset in mice on a homozygote H2k/k background
• the ratio of T cell subsets in the thymus is skewed toward CD8 T cells on a heterozygote H2b/k background
|
cellular
• CD4 T cells expressing the transgenic TCR proliferate in response to hen egg lysozyme
• proliferation occurs whether CD4 T cells are low or high expressers of the transgenic TCR-alpha chain
|