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Phenotypes Associated with This Genotype
Genotype
MGI:3799684
Allelic
Composition
Tg(TcrHEL3A9)1Mmd/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * C57BR/cd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcrHEL3A9)1Mmd mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• there is a skewing towards the CD-4 T cell subset in mice on a homozygote H2k/k background
• the ratio of T cell subsets in the thymus is skewed toward CD8 T cells on a heterozygote H2b/k background
• 55.9% of the double-positive thymocytes express the transgenic TCR
• 15% of total lymphocytes found in lymph nodes are CD4 T cells bearing the transgenic TCR
• CD4 T cells that express the transgenic TCR-beta chain also express low or high amounts of the TCR-alpha chain
• the CD4 T cells expressing the low amounts of transgenic TCR-alpha may also express endogenous TCR-alpha chains
• CD 4 T cell numbers in the lymph nodes are reduced by about a third
• in vitro TCR stimulation leads to reduced expression of CD69 compared to T cells from mice transgenic for just the TCR
• CD4 T cells expressing the transgenic TCR proliferate in response to hen egg lysozyme
• proliferation occurs whether CD4 T cells are low or high expressers of the transgenic TCR-alpha chain

hematopoietic system
• there is a skewing towards the CD-4 T cell subset in mice on a homozygote H2k/k background
• the ratio of T cell subsets in the thymus is skewed toward CD8 T cells on a heterozygote H2b/k background
• 55.9% of the double-positive thymocytes express the transgenic TCR
• 15% of total lymphocytes found in lymph nodes are CD4 T cells bearing the transgenic TCR
• CD4 T cells that express the transgenic TCR-beta chain also express low or high amounts of the TCR-alpha chain
• the CD4 T cells expressing the low amounts of transgenic TCR-alpha may also express endogenous TCR-alpha chains
• CD 4 T cell numbers in the lymph nodes are reduced by about a third
• in vitro TCR stimulation leads to reduced expression of CD69 compared to T cells from mice transgenic for just the TCR
• CD4 T cells expressing the transgenic TCR proliferate in response to hen egg lysozyme
• proliferation occurs whether CD4 T cells are low or high expressers of the transgenic TCR-alpha chain

endocrine/exocrine glands
• there is a skewing towards the CD-4 T cell subset in mice on a homozygote H2k/k background
• the ratio of T cell subsets in the thymus is skewed toward CD8 T cells on a heterozygote H2b/k background

cellular
• CD4 T cells expressing the transgenic TCR proliferate in response to hen egg lysozyme
• proliferation occurs whether CD4 T cells are low or high expressers of the transgenic TCR-alpha chain


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory