Analysis Tools
cellular
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• after 2 months of age
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• in mice supplemented with zinc
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endocrine/exocrine glands
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• at 6 weeks of age, zinc treated females exhibit a delay in epithelium penetration into the mesenchymal fat pad compared to wild-type mice
• at 7 weeks of age, active epithelial cells are located in the subtending duct as well as the end bud region compared to wild-type mice in which active cells are only located in the end bud region
• however, by week 12 mammary development is normal
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• the pancreas shows progressive hyperplasia of the stroma, tubular structures, and florid ductular metaplasia
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• exposure to zinc increases severity of lesions
• older mice exhibit severe perilobular and intralobular fibrosis
• pancreatic fibrosis is less severe in zinc restricted mice
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liver/biliary system
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• mice exhibit progressive liver lesions that begin after 2 months of age with karyomegaly and cytomegaly of hepatocytes
• at 7 to 8 months of age, mice exhibit foci's heterogeneity of cell size and cellular dysplasia in the liver
• mice exhibit single to multiple foci liver nodules of 0.5 cm in diameter or greater
• liver lesions develop in a progressive fashion, with neoplasia confirmed at autopsy
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• in severe cases mice exhibit enlarged livers due to the presence of nodular masses
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• after 2 months of age, mice exhibit foci of hepatocytes that exhibit karyomegaly and cytomegaly
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• after 2 months of age
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• mice exhibit heptatocellular carcinomas that are none metastatic
• exposure to zinc increases severity of lesions
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renal/urinary system
kidney cyst
(
J:20315
)
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• female mice supplemented with zinc exhibit renal cysts of distal tubule origins unlike in similarly treated wild-type mice
• renal cysts in female mice supplemented with zinc are frequently associated with fibrosis
• occasionally cysts are of proximal tubular origins
• some male mice supplemented with zinc exhibit renal cysts
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• in female mice supplemented with zinc compared to similarly treated wild-type mice
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• mice supplemented with zinc exhibit increased mesangial compartments due to increased mesangial cell numbers and space compared to similarly treated wild-type mice
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• in mice supplemented with zinc
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• in mice supplemented with zinc
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• mice supplemented with zinc exhibit enlarged glomeruli compared to similarly treated wild-type mice
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• renal cysts in female mice supplemented with zinc are frequently associated with fibrosis
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neoplasm
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• mice exhibit heptatocellular carcinomas that are none metastatic
• exposure to zinc increases severity of lesions
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growth/size/body
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• in mice supplemented with zinc compared to similarly treated wild-type mice
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kidney cyst
(
J:20315
)
|
• female mice supplemented with zinc exhibit renal cysts of distal tubule origins unlike in similarly treated wild-type mice
• renal cysts in female mice supplemented with zinc are frequently associated with fibrosis
• occasionally cysts are of proximal tubular origins
• some male mice supplemented with zinc exhibit renal cysts
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• in female mice supplemented with zinc compared to similarly treated wild-type mice
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• in severe cases mice exhibit enlarged livers due to the presence of nodular masses
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immune system
| N |
• mice are not diabetic and have no obvious inflammatory reaction
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integument
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• at 6 weeks of age, zinc treated females exhibit a delay in epithelium penetration into the mesenchymal fat pad compared to wild-type mice
• at 7 weeks of age, active epithelial cells are located in the subtending duct as well as the end bud region compared to wild-type mice in which active cells are only located in the end bud region
• however, by week 12 mammary development is normal
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