Phenotypes Associated with This Genotype

Genotype
MGI:3799624

• Allelic Composition: C3^tm1Crr/C3^tm1Crr
• Genetic Background: B6;129S4-C3^tm1Crr/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating free fatty acids level ( J:214214 )

• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age

immune system

increased susceptibility to bacterial infection ( J:136745 )

• mice infected with 500 CFU of S. aureus, show higher numbers of bacterial SFU (intraocular growth) at 24 and 48 hours post-infection, levels are indistinguishable from infected wild-type by 72 hours

decreased susceptibility to Coronaviridae infection ( J:286325 )

• mice show partial protection from intranasal infection with the mouse-adapted SARS-CoV MA15 compared to wild-type controls, showing no significant weight loss, decreased airway resistance associated with airway debris and exhalation force indicating improved respiratory function, reduced lung pathology, reductions in inflammatory monocytes and neutrophils and increases in dendritic cells and alveolar macrophages in the lungs by day 4 postinfection, and reduction in cytokine and chemokine responses in the lungs

• SARS-CoV MA15-infected mice exhibit more airspace inflammation at day 2 postinfection than controls but his is reversed later in infection

• however, SARS-CoV MA15-infected mice show similar levels of viral titers in the lung and ratio of peak expiratory flow as in controls

vision/eye

vision/eye phenotype ( J:136745 )

N • eyes infected with 500 CFU S. aureus show mild signs of inflammation at 24 and 48 hours but appear normal at 72 hours

abnormal retina rod bipolar cell morphology ( J:214214 )

• the number of rod bipolar cells is decreased at 14 months of age

abnormal retina horizontal cell morphology ( J:214214 )

• density of horizontal cells is decreased

decreased b-wave amplitude ( J:214214 )

• ERG b-waves are decreased at 12 months of age but not at younger ages

abnormal c-wave shape ( J:214214 )

• the amplitude of the c-wave is reduced at 12 months of age, but not at 8 weeks of age

• however, no other component of the dc-ERG is different

abnormal eye electrophysiology ( J:136745 )

• 24 hours after infection with 500 CFU of S. aureus, mice show a transient loss of b-wave amplitude; this stabilizes at a level of 66% of baseline values, similar to what is seen in eyes of infected wild-type mice

nervous system

abnormal retina rod bipolar cell morphology ( J:214214 )

• the number of rod bipolar cells is decreased at 14 months of age

abnormal retina horizontal cell morphology ( J:214214 )

• density of horizontal cells is decreased