Phenotypes Associated with This Genotype

Genotype
MGI:3799447

• Allelic Composition: Tg(MMTVneu)202Mul/0; Tg(Trp53R172H)8512Jmr/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:40336 )

• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days

• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone

• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone

• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

cellular

aneuploidy ( J:40336 )

• tumors exhibit aneuploidy and tetraploidy unlike in tumors from mice expressing Tg(MMTVneu)202Mul alone that are euploidy

polyploidy ( J:40336 )

• tumors exhibit aneuploidy and tetraploidy unlike in tumors from mice expressing Tg(MMTVneu)202Mul alone that are euploidy

integument

increased mammary gland tumor incidence ( J:40336 )

• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days

• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone

• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone

• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:40336 )

• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days

• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone

• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone

• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone