Analysis Tools
mortality/aging
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• most mice die by 11 to 12 weeks of age due to overgrowth of the poorly differentiated and invasive carcinoma and lung metastases
• all mice die prior to 18 weeks of age
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neoplasm
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• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice
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• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age
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• mice exhibit lung metastases
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endocrine/exocrine glands
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• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice
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• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age
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digestive/alimentary system
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• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice
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integument
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• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age
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respiratory system
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• mice exhibit lung metastases
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craniofacial
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• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice
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growth/size/body
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• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice
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