Phenotypes Associated with This Genotype

Genotype
MGI:3799372

• Allelic Composition: Tg(TcrHEL3A9)1Mmd/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive, alpha beta T cell morphology ( J:73608 )

• vast majority of CD4 T cells express a T cell receptor that is specific for hen egg lysozyme (HEL) antigen

abnormal T cell activation ( J:73608 )

• CD4 T cells become activated when cultured with HEL protein and B cells from Tg(IghelMD4)4Ccg transgenic mice

• 12 hours of culture leads to upregulation of CD69 on the cell surface

• CD4 T cells enlarge into blasts and express high levels of CD44 after 48 hours in culture

• supernatant from these cultures supports a IL-2/IL-4 dependent cell line

• the use of HEL peptide leads to similar but somewhat reduced levels of activation

increased T cell proliferation ( J:73608 )

abnormal interleukin secretion ( J:73608 )

• CD4 T cells become activated and secrete cytokines when cultured with HEL protein and B cells from Tg(IghelMD4)4Ccg transgenic mice

• supernatant from these cultures supports a IL-2/IL-4 dependent cell line

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:73608 )

• vast majority of CD4 T cells express a T cell receptor that is specific for hen egg lysozyme (HEL) antigen

abnormal T cell activation ( J:73608 )

• CD4 T cells become activated when cultured with HEL protein and B cells from Tg(IghelMD4)4Ccg transgenic mice

• 12 hours of culture leads to upregulation of CD69 on the cell surface

• CD4 T cells enlarge into blasts and express high levels of CD44 after 48 hours in culture

• supernatant from these cultures supports a IL-2/IL-4 dependent cell line

• the use of HEL peptide leads to similar but somewhat reduced levels of activation

increased T cell proliferation ( J:73608 )

cellular

increased T cell proliferation ( J:73608 )