Phenotypes Associated with This Genotype

Genotype
MGI:3799370

• Allelic Composition: Tg(IghelMD4)4Ccg/0; Tg(ML5sHEL)5Ccg/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:76134 )

• peripheral B cells are reduced compared to in Tg(IghelMD4)4Ccg mice

decreased marginal zone B cell number ( J:132538 )

• very few B cells in the spleen have surface markers indicative of the marginal zone phenotype

abnormal spleen primary B follicle morphology ( J:76134 )

• the number of B follicles is decreased compared to in Tg(IghelMD4)4Ccg mice

abnormal B cell physiology ( J:76134 )

• surface levels of IgMa are decreased 7- to 11-fold compared to in Tg(IghelMD4)4Ccg mice

abnormal B cell anergy ( J:73608 , J:132538 )

• B cells from these mice are unable to activate HEL-specific CD4 T cells from Tg(TcrHEL3A9)1Mmd mice when co-cultured together in the presence of HEL protein (J:73608)

• B cells are anergic when stimulated with HEL antigen as determined by reduced antibody production, no upregulation of activation markers CD69 and CD86, and failure to increase size (J:132538)

hematopoietic system

decreased B cell number ( J:76134 )

• peripheral B cells are reduced compared to in Tg(IghelMD4)4Ccg mice

decreased marginal zone B cell number ( J:132538 )

• very few B cells in the spleen have surface markers indicative of the marginal zone phenotype

abnormal spleen primary B follicle morphology ( J:76134 )

• the number of B follicles is decreased compared to in Tg(IghelMD4)4Ccg mice

abnormal B cell physiology ( J:76134 )

• surface levels of IgMa are decreased 7- to 11-fold compared to in Tg(IghelMD4)4Ccg mice