Phenotypes Associated with This Genotype

Genotype
MGI:3799265

• Allelic Composition: Tex11^tm1.1Jpt/Y
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:136834 )

♂N • despite meiotic abnormalities mice are fertile and produce normal sized litters

abnormal spermatogenesis ( J:136834 )

♂ • slight but significant increase in the percentage of zygotene cells during the semi-synchronous first wave of meiosis at P12

♂ • increase in the number of apoptotic cells in stage XII tubules but no change in overall proportion of apoptotic cells when all tubules are examined

abnormal male meiosis ( J:136834 )

♂ • staining indicates an increase in the number of double strand break repair foci in pachytene cells in adult males

♂ • decrease in mean autosomal crossovers, about half as many double exchange bivalents, and an increase in the proportion of double-exchange synaptonemal complexes with short inter-crossover distances

♂ • the proportion of spindles with laggard chromosomes is increased to 12.9% compared to 5.6% in controls and the proportion of achiasmate XY and autosomal chromosomes are increased

♂ • double strand break formation and early steps of repair appear similar to controls

♂ • no increase in the percentage of aneuploid cells is detected