Phenotypes Associated with This Genotype

Genotype
MGI:3799122

• Allelic Composition: Nfkb1^tm1Bal/Nfkb1^tm1Bal; Rela^tm1Bal/Rela^tm1Bal
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal dendritic cell differentiation ( J:113514 )

• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells

• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors

• however, myeloid precursor cells are normal

decreased dendritic cell number ( J:113514 )

• in culture, very few dendritic cells differentiate from bone marrow cells

immune system

abnormal dendritic cell differentiation ( J:113514 )

• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells

• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors

• however, myeloid precursor cells are normal

decreased dendritic cell number ( J:113514 )

• in culture, very few dendritic cells differentiate from bone marrow cells

cellular

abnormal dendritic cell differentiation ( J:113514 )

• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells

• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors

• however, myeloid precursor cells are normal