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Phenotypes Associated with This Genotype
Genotype
MGI:3798863
Allelic
Composition		 Foxn1nu/Foxn1nu
Gpc1tm1.1Alan/Gpc1tm1.1Alan
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (106 available)
Gpc1tm1.1Alan mutation (2 available); any Gpc1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:130809 )
• athymic mutants exhibit decreased tumor angiogenesis and metastasis following intrapancreatic implantation with either PANC-1 or T3M4 human pancreatic cancer cells and fewer pulmonary metastates following intravenous injection of murine B16-F10 melanoma cells

homeostasis/metabolism
abnormal response/metabolism to endogenous compounds ( J:130809 )
• isolated hepatic endothelial cells exhibit an attenuated mitogenic response to VEGF-A, with cells showing a smaller increase in cell proliferation than wild-type in response to VEGF-A

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory