Phenotypes Associated with This Genotype

Genotype
MGI:3798775

• Allelic Composition: Myf5^tm2Tajb/Myf5^tm2Tajb
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:168843 )

N • genotoxins suppress skeletal myogenesis as in wild-type mice

abnormal skeletal muscle satellite cell proliferation ( J:128921 )

• in culture, satellite cells exhibit decreased proliferation compared to wild-type cells

abnormal eye muscle development ( J:150130 )

• the extraocular muscle anlage is hypoplastic in some mice compared to in wild-type mice

abnormal skeletal muscle morphology ( J:128921 )

increased skeletal muscle fiber diameter ( J:128921 )

• muscle fiber diameter is increased compared to wild-type mice

increased variability of skeletal muscle fiber size ( J:128921 )

• muscles contain fibers of varying diameters

centrally nucleated skeletal muscle fibers ( J:128921 )

• muscles contain fibers with centrally located nuclei

skeletal muscle fibrosis ( J:128921 )

• at 7 months of age mice, develop more fibrosis of the connective tissue than wild-type mice

• fibrosis of connective tissue following muscle injury is increased compared to in similarly treated wild-type mice

abnormal muscle regeneration ( J:128921 )

• muscle regeneration is delayed and accompanied by endomysial fibrosis, muscle fiber hypertrophy, increased fiber diameter heterogeneity, and fat accumulation unlike in wild-type mice

vision/eye

abnormal eye muscle development ( J:150130 )

• the extraocular muscle anlage is hypoplastic in some mice compared to in wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:168843 )

N • genotoxins suppress skeletal myogenesis as in wild-type mice

cellular

abnormal skeletal muscle satellite cell proliferation ( J:128921 )

• in culture, satellite cells exhibit decreased proliferation compared to wild-type cells