Phenotypes Associated with This Genotype

Genotype
MGI:3798632

• Allelic Composition: Dmd^mdx-3Cv/Y
• Genetic Background: B6.Cg-Dmd^mdx-3Cv/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:134272 )

♂ • skeletal muscles exhibit variation in fiber size and centrally located nuclei unlike in wild-type mice

♂ • mice exhibit macrophage invasion into muscles unlike in wild-type mice

increased variability of skeletal muscle fiber size ( J:134272 )

♂

centrally nucleated skeletal muscle fibers ( J:134272 )

♂

abnormal muscle contractility ( J:134272 )

♂ • highest specific tetanic force is lower than in wild-type mice

♂ • at high frequencies mice titanic force is greater than in Dmd^mdx-4Cv mice

♂ • following eccentric contraction damage, force is reduced to unlike in wild-type mice that experience only a moderate drop in force but not as severely as in Dmd^mdx-4Cv mice

♂ • age exacerbates force losses

vision/eye

vision/eye phenotype ( J:53822 )

♂N • retina morphology is normal

abnormal Muller cell morphology ( J:125566 )

♂ • mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells

abnormal eye electrophysiology ( J:53822 )

♂ • mice exhibit a severely attenuated b-wave amplitude compared to wild-type mice

♂ • b-wave and OP3 wave implicit times are delayed compared to in wild-type mice

♂ • derived positive (P2) responses are delayed compared to in wild-type mice

behavior/neurological

abnormal grip strength ( J:134272 )

♂ • mice exhibit stronger grip strength than Dmd^mdx-4Cv mice

nervous system

abnormal Muller cell morphology ( J:125566 )

♂ • mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells

cellular

abnormal Muller cell morphology ( J:125566 )

♂ • mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells