Mouse Genome Informatics
ht
    Del(5Letm1-D5Mit81)3Jcs/+
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

growth/size/body
• severe growth retardation averaging only 50-80% ofthe weight of same-sex wildtype littermates

craniofacial
• Background Sensitivity: the 'Greek warrior helmet' phenotype of domed skull, small ears, and wide set eyes is found on a >50% C57BL/6J background, but is less evident on other backgrounds

hearing/vestibular/ear

limbs/digits/tail

vision/eye

behavior/neurological
• more than 85% of heterozygotes seize in response to a high frequency electroconvulsive stimulus

nervous system
• more than 85% of heterozygotes seize in response to a high frequency electroconvulsive stimulus

Mouse Models of Human Disease
OMIM IDRef(s)
Wolf-Hirschhorn Syndrome; WHS 194190 J:67077