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Phenotypes Associated with This Genotype
Genotype
MGI:3798284
Allelic
Composition
Del(5D5Mit148-Qdpr)2Jcs/+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• Background Sensitivity: severe growth retardation such that females are approximately 60% of wildtype weight and males are approximately 50% of wildtype weight between 4 and 12 weeks of age

craniofacial
• Background Sensitivity: the 'Greek warrior helmet' phenotype of domed skull, small ears, and wide set eyes is found on a >50% C57BL/6J background, but is less evident on other backgrounds

hearing/vestibular/ear

skeleton

vision/eye
N
• no corneal opacities are found

limbs/digits/tail

behavior/neurological
N
• Morris water maze performance normal
• froglike gait with hindlimbs splayed outward during locomotion

nervous system
• intraculminate fissue, posterior fissure, and uvular cus are lacking
• hypoplasia of the cerebral cortex results in colliculi being more exposed

Mouse Models of Human Disease
OMIM ID Ref(s)
Wolf-Hirschhorn Syndrome; WHS 194190 J:67077


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory