Mouse Genome Informatics
ht
    Del(5D5Mit148-Qdpr)2Jcs/+
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

growth/size
• Background Sensitivity: severe growth retardation such that females are approximately 60% of wildtype weight and males are approximately 50% of wildtype weight between 4 and 12 weeks of age

craniofacial
• Background Sensitivity: the 'Greek warrior helmet' phenotype of domed skull, small ears, and wide set eyes is found on a >50% C57BL/6J background, but is less evident on other backgrounds

hearing/vestibular/ear

skeleton

vision/eye
N
• no corneal opacities are found (J:67077)

limbs/digits/tail

behavior/neurological
N
• Morris water maze performance normal (J:67077)
• froglike gait with hindlimbs splayed outward during locomotion

nervous system
• intraculminate fissue, posterior fissure, and uvular cus are lacking
• hypoplasia of the cerebral cortex results in colliculi being more exposed

Mouse Models of Human Disease
OMIM IDRef(s)
Wolf-Hirschhorn Syndrome; WHS 194190 J:67077