Analysis Tools
skeleton
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• total volumetric bone mineral density is decreased compared to in wild-type mice
• however, areal bone mineral density in the femur and lumbar spine is normal
• cortical volumetric bone mineral density in the tibial metaphysis is decreased
• however, cortical volumetric bone mineral densities in the tibial diaphysis and at the lumbar vertebrae are normal
• unlike wild-type mice, cortical bone mineral density is unresponsive to ovariectomization or estrogen replacement
• unlike wild-type mice, high doses of estrogen results in an inhibitory effect on cortical volumetric bone mineral density at the diaphysis
• ovariectomized mice treated with estrogen replacement exhibit no prevention of bone loss in the femur areal volumetric bone mineral density
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• trabecular volumetric bone mineral density is increased at the tibial metaphysis and the spine compared to in wild-type mice
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• estradiol-treated, ovariectomized mice fail to exhibit an increase in total body areal bone mineral density (aBMD), trabecular bone parameters (trabecular bone volume and trabecular number), and cortical bone parameters unlike similarly treated wild-type mice
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• unlike wild-type mice, mineral apposition rates are insensitive to ovariectomization and estrogen treatment
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reproductive system
| N |
• mice exhibit normal numbers of gonocytes
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• decreased uterine weight cannot be restored by treatment with estrogen
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hematopoietic system
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• estradiol-treated, ovariectomized mice fail to exhibit a decrease in thymus weight unlike similarly treated wild-type mice
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• estradiol-treated, ovariectomized mice fail to exhibit an increase in IgG, IgM, and IgA secretion unlike in similarly treated wild-type mice
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• estradiol-treated, ovariectomized mice fail to exhibit a decrease in bone marrow cellularity and B lymphocytes unlike similarly treated wild-type mice
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homeostasis/metabolism
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• in female mice
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• in female mice
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• in female mice
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• estradiol-treated, ovariectomized mice fail to exhibit an affect on total body areal bone mineral density (aBMD), trabecular bone parameters (trabecular bone volume and trabecular number), cortical bone parameters, bone marrow parameters, or non-bone parameters (uterus, thymus, and liver weights) unlike similarly treated wild-type mice
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immune system
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• estradiol-treated, ovariectomized mice fail to exhibit a decrease in thymus weight unlike similarly treated wild-type mice
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• estradiol-treated, ovariectomized mice fail to exhibit an increase in IgG, IgM, and IgA secretion unlike in similarly treated wild-type mice
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behavior/neurological
| N |
• mice exhibit normal anxiety-related behavior
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• in female mice in an open field likely due to obesity
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growth/size/body
endocrine/exocrine glands
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• estradiol-treated, ovariectomized mice fail to exhibit a decrease in thymus weight unlike similarly treated wild-type mice
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