Phenotypes Associated with This Genotype

Genotype
MGI:3798199

• Allelic Composition: Esr1^tm1.1Lja/Esr1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

enlarged endometrial glands ( J:79228 )

♀ • mice exhibit grossly enlarged endometrial glands filled with secretory material that progresses with age

abnormal ovary morphology ( J:79228 )

♀ • unlike in wild-type mice, ovarian stroma is increased and stromal cells contain cytoplasmic vacuoles (lipid droplets)

absent corpus luteum ( J:79228 )

♀

abnormal tertiary ovarian follicle morphology ( J:79228 )

♀ • antral follicles exhibit a cystic appearance and are increased in size compared to in wild-type mice

uterus cyst ( J:79228 )

♀ • mice exhibit cystic endometrial hyperplasia such as grossly enlarged endometrial glands filled with secretory material that progresses with age

endometrium hyperplasia ( J:79228 )

♀ • mice exhibit cystic endometrial hyperplasia

enlarged uterus ( J:79228 )

♀ • unlike in wild-type mice, uteri are elongated and heavier

increased uterus weight ( J:79228 )

♀ • increases in uterine weight are more pronounced with age

decreased ovulation rate ( J:79228 )

♀ • antral follicles exhibit a cystic appearance and are increased in size compared to in wild-type mice

abnormal uterus physiology ( J:79228 )

♀ • uterine tissue is hypersensitive to estrogen treatment

♀ • however, uterine and vaginal tissues in an ovariectomized female respond normally to estrogen

female infertility ( J:79228 )

♀ • while male mice are fertile, female mice are infertile

homeostasis/metabolism

decreased circulating progesterone level ( J:79228 )

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:79228 )

♀ • female mice fail to exhibit side-branching and differentiation of ductal buds into lobuoalveolar structures

♀ • branch points are decreased in number and alveolar bud formation is impaired

enlarged endometrial glands ( J:79228 )

♀ • mice exhibit grossly enlarged endometrial glands filled with secretory material that progresses with age

abnormal ovary morphology ( J:79228 )

♀ • unlike in wild-type mice, ovarian stroma is increased and stromal cells contain cytoplasmic vacuoles (lipid droplets)

absent corpus luteum ( J:79228 )

♀

abnormal tertiary ovarian follicle morphology ( J:79228 )

♀ • antral follicles exhibit a cystic appearance and are increased in size compared to in wild-type mice

integument

abnormal branching of the mammary ductal tree ( J:79228 )

♀ • female mice fail to exhibit side-branching and differentiation of ductal buds into lobuoalveolar structures

♀ • branch points are decreased in number and alveolar bud formation is impaired

growth/size/body

uterus cyst ( J:79228 )

♀ • mice exhibit cystic endometrial hyperplasia such as grossly enlarged endometrial glands filled with secretory material that progresses with age