Phenotypes Associated with This Genotype

Genotype
MGI:3798180

• Allelic Composition: Esr1^tm1Geog/Esr1^tm1Geog
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

impaired granulosa cell differentiation ( J:135981 )

♀ • granulosa cells do not encapsulate into follicles

absent corpus luteum ( J:135981 )

♀

increased tertiary ovarian follicle number ( J:135981 )

♀ • female mice have more antral follicles than in wild-type mice; theca cells are hyperplastic

♀ • 89% of mice develop hemorrhagic cysts from atretic antral follicles

increased theca cell number ( J:135981 )

♀ • theca cells are hyperplastic

ovarian follicular cyst ( J:135981 )

♀ • 89% of mice develop hemorrhagic cysts from atretic antral follicles

abnormal uterus morphology ( J:135981 )

♀ • uterine tissues are hypoplastic and lacks edematous stroma

small uterus ( J:135981 )

♀ • at 12 weeks of age

uterus hypoplasia ( J:135981 )

♀

abnormal vagina morphology ( J:135981 )

♀ • vaginal tissues are hypoplastic and lack cornification

vagina hypoplasia ( J:135981 )

♀

anovulation ( J:135981 )

♀ • female mice are anovulatory

female infertility ( J:135981 )

♀

homeostasis/metabolism

increased circulating testosterone level ( J:135981 )

• 8-fold

increased circulating estradiol level ( J:135981 )

• 3.5-fold

increased circulating luteinizing hormone level ( J:135981 )

• 12-fold

abnormal response/metabolism to endogenous compounds ( J:135981 )

• unlike in wild-type mice, IGF-I treatment induces irregular uterine epithelial proliferation

decreased physiological sensitivity to xenobiotic ( J:135981 )

• postnatal treatment with propyl pyrazole triol fails to rescue mammary gland ductal growth

• unlike in wild-type mice, moderate diethylstilbestrol treatment fails to induce a uterine response

• however, mice respond normally to a high dose of diethylstilbestrol and propyl pyrazole triol treatment of adult females induces uterine and mammary gland ductal growth

growth/size/body

ovarian follicular cyst ( J:135981 )

♀ • 89% of mice develop hemorrhagic cysts from atretic antral follicles

increased body size ( J:135981 )

• in female mice

increased body weight ( J:135981 )

• at 12 and 20 weeks of age female mice weight 19% and 33% more than wild-type mice

adipose tissue

increased gonadal fat pad weight ( J:135981 )

• at 20 weeks of age, gonadal fat pads in female mice are 35% larger than in wild-type mice

increased mammary fat pad weight ( J:135981 )

• at 20 weeks of age, mammary fat pads in female mice are 43% larger than in wild-type mice

endocrine/exocrine glands

impaired granulosa cell differentiation ( J:135981 )

♀ • granulosa cells do not encapsulate into follicles

abnormal mammary gland development ( J:135981 )

♀ • mammary glands fail to develop beyond a rudimentary epithelial ductal tree

absent corpus luteum ( J:135981 )

♀

increased tertiary ovarian follicle number ( J:135981 )

♀ • female mice have more antral follicles than in wild-type mice; theca cells are hyperplastic

♀ • 89% of mice develop hemorrhagic cysts from atretic antral follicles

increased theca cell number ( J:135981 )

♀ • theca cells are hyperplastic

ovarian follicular cyst ( J:135981 )

♀ • 89% of mice develop hemorrhagic cysts from atretic antral follicles

integument

abnormal mammary gland development ( J:135981 )

♀ • mammary glands fail to develop beyond a rudimentary epithelial ductal tree

cellular

impaired granulosa cell differentiation ( J:135981 )

♀ • granulosa cells do not encapsulate into follicles