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Phenotypes Associated with This Genotype
Genotype
MGI:3797748
Allelic
Composition		 Opn4tm1Yau/Opn4tm4(DTA)Saha
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1Yau mutation (0 available); any Opn4 mutation (33 available)
Opn4tm4(DTA)Saha mutation (0 available); any Opn4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina ganglion cell morphology ( J:134780 )
• only 17.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls
• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus

nervous system
abnormal suprachiasmatic nucleus morphology ( J:134780 )
• few fibers innervate the SCN from the retinal ganglion cells
abnormal retina ganglion cell morphology ( J:134780 )
• only 17.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls
• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory