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Phenotypes Associated with This Genotype
Genotype
MGI:3797716
Allelic
Composition
Myocdtm1Msp/Myocdtm1Msp
Tg(Pax3-cre)1Joe/0
Genetic
Background
involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myocdtm1Msp mutation (0 available); any Myocd mutation (31 available)
Tg(Pax3-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• all mutants at P2 exhibit patent ductus arteriosus
• E16.5 mutants exhibit diminished expression of smooth muscle cell contractile proteins in the ductus arteriosus
• however, patterning of the cardiac outflow tract and great arteries is normal

cellular
• all mutants at P2 exhibit patent ductus arteriosus
• E16.5 mutants exhibit diminished expression of smooth muscle cell contractile proteins in the ductus arteriosus
• however, patterning of the cardiac outflow tract and great arteries is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
patent ductus arteriosus DOID:13832 OMIM:607411
J:131288


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory