immune system
• significant reduction in size of the thymus with cellularity decreased almost 3-fold
• the percentage of apoptotic cells in the thymus is doubled
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• unproductive transcripts with premature stop codons is detectable in 29% of single positive T cells
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• there is a 3-fold reduction in the number of double positive T cells found in the thymus
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• there is a 4- to 5-fold reduction in CD4 T cells found in the thymus
• the number of CD4 T cells found in the periphery is 30% that of wild-type
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• there is a 2-fold to 3-fold reduction in T cell numbers
• the number of CD8 T cells found in the periphery is 30% that of wild-type
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hematopoietic system
• significant reduction in size of the thymus with cellularity decreased almost 3-fold
• the percentage of apoptotic cells in the thymus is doubled
|
• unproductive transcripts with premature stop codons is detectable in 29% of single positive T cells
|
• there is a 3-fold reduction in the number of double positive T cells found in the thymus
|
• there is a 4- to 5-fold reduction in CD4 T cells found in the thymus
• the number of CD4 T cells found in the periphery is 30% that of wild-type
|
• there is a 2-fold to 3-fold reduction in T cell numbers
• the number of CD8 T cells found in the periphery is 30% that of wild-type
|
endocrine/exocrine glands
• significant reduction in size of the thymus with cellularity decreased almost 3-fold
• the percentage of apoptotic cells in the thymus is doubled
|