About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3797492
Allelic
Composition
Tg(Lck-cre)548Jxm/?
Upf2tm1Btp/Upf2tm1Btp
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)548Jxm mutation (2 available)
Upf2tm1Btp mutation (0 available); any Upf2 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• significant reduction in size of the thymus with cellularity decreased almost 3-fold
• the percentage of apoptotic cells in the thymus is doubled
• unproductive transcripts with premature stop codons is detectable in 29% of single positive T cells
• there is a 3-fold reduction in the number of double positive T cells found in the thymus
• there is a 4- to 5-fold reduction in CD4 T cells found in the thymus
• the number of CD4 T cells found in the periphery is 30% that of wild-type
• there is a 2-fold to 3-fold reduction in T cell numbers
• the number of CD8 T cells found in the periphery is 30% that of wild-type

hematopoietic system
• significant reduction in size of the thymus with cellularity decreased almost 3-fold
• the percentage of apoptotic cells in the thymus is doubled
• unproductive transcripts with premature stop codons is detectable in 29% of single positive T cells
• there is a 3-fold reduction in the number of double positive T cells found in the thymus
• there is a 4- to 5-fold reduction in CD4 T cells found in the thymus
• the number of CD4 T cells found in the periphery is 30% that of wild-type
• there is a 2-fold to 3-fold reduction in T cell numbers
• the number of CD8 T cells found in the periphery is 30% that of wild-type

endocrine/exocrine glands
• significant reduction in size of the thymus with cellularity decreased almost 3-fold
• the percentage of apoptotic cells in the thymus is doubled


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory