Phenotypes Associated with This Genotype

Genotype
MGI:3797109

• Allelic Composition: Tnfsf15^tm1Cdon/Tnfsf15^tm1Cdon
• Genetic Background: B6.129-Tnfsf15^tm1Cdon

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal dendritic cell differentiation ( J:136280 )

• mutant dendritic cells (DCs) exhibit reduced potency to indue Th17 differentiation and proliferation in vitro

• mutant mice appeared phenotypically normal, and similar immune cell numbers and proportions were observed in the lymph nodes, spleen, thymus, and bone marrow

immune system

abnormal dendritic cell differentiation ( J:136280 )

• mutant dendritic cells (DCs) exhibit reduced potency to indue Th17 differentiation and proliferation in vitro

• mutant mice appeared phenotypically normal, and similar immune cell numbers and proportions were observed in the lymph nodes, spleen, thymus, and bone marrow

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:136280 )

• in a Th17-mediated autoimmune disease model, myelin oligodendrocyte glycoprotein induced EAE, mutant mice showed a significantly reduced disease severity

cellular

abnormal dendritic cell differentiation ( J:136280 )

• mutant dendritic cells (DCs) exhibit reduced potency to indue Th17 differentiation and proliferation in vitro

• mutant mice appeared phenotypically normal, and similar immune cell numbers and proportions were observed in the lymph nodes, spleen, thymus, and bone marrow