Phenotypes Associated with This Genotype

Genotype
MGI:3797083

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Trpv1,ECFP)Mde}/Gt(ROSA)26Sor⁺; Tg(Nes-cre)1Wme/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:136582 )

N • capsaicin infusion into striatum does not affect exploratory or motor behavior in Cre-activated mutants or controls

circling ( J:136582 )

• infusion of capsaicin into striatum of results in stereotyped contralateral circling behavior within 5 minutes of delivery, while control mice without activation of Trpv1 show no effect

nervous system

increased susceptibility to neuronal excitotoxicity ( J:136582 )

• infusion of high doses of capsaicin (5-10 um) into striatum results in dose-dependent excitotoxicity in neuronal cultures

• at doses sufficient to induce circling, no cell death is observed

abnormal single cell response ( J:136582 )

• in layer 5 cortical slices, capsaicin induces action potentials while cells from Cre-negative animals show no response

• neurons in slices show dose-dependent depolarizing currents in response to capsaicin applied to the bath

• capsaicin applied acutely to single cells causes reproducible bursts of action potentials with increases in firing rate; frequency of firing is dependent on duration and concentration of capsaicin application

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:136582 )

• infusion of high doses of capsaicin (5-10 um) into striatum results in dose-dependent excitotoxicity in neuronal cultures

• at doses sufficient to induce circling, no cell death is observed

cellular

increased susceptibility to neuronal excitotoxicity ( J:136582 )

• infusion of high doses of capsaicin (5-10 um) into striatum results in dose-dependent excitotoxicity in neuronal cultures

• at doses sufficient to induce circling, no cell death is observed